Facts about Viagra


Sufferers with diastolic dysfunction after a heart attack: can sildenafil improve their condition?

Sildenafil lowers blood pressure in patients with diastolic dysfunction caused by heart attack when exercising or resting.

Dr. Copenhagen’s Mads J. Andersen wanted to investigate the effect of the PDE-5 inhibitor in men who suffer from increased blood pressure when exercising to clarify whether inhibitors can help prevent the transformation of asymptomatic heart failure into symptomatic┬áViagra side effects.

Dr. Andersen has explained the cause of his investigation. People from this group have higher mortality rates. Physically, they are also more vulnerable.

According to Dr. Andersen’s patients leave the hospital too soon. They believe that they feel well and need no medical attention. Patients can not understand that they risk very much. Abnormal pressure is not obvious. During the exercises, they can get the heart attack. Some develop pulmonary edema.

When patients are taking sildenafil, unadapted remodeling of the myocardium is reduced despite possible problems with blood pressure. Sildenafil is able to potentiate vasodilation. The researchers claim that this brings positive hemodynamic effects without risking system hypertension.

In order to investigate the effect of the drug Viagra effect on patients suffering from diastolic dysfunction and having problems with ejaculation, 70% of patients received sildenafil 40 mg. Others got placebo. Medications were taken three times a day. Duration of the investigation was 9 weeks. 61% of the subjects were men. Time interval from myocardial infarction to randomization was 32 days (average).

Before randomization and during the examination, patients were given ultrasound and right heart catheterization during exercises and at rest. PCWP (Pulmonary Capillary Closure Pressure) was the main objective of the study.

Lead investigator and his colleagues have demonstrated that pulmonary capillary closure pressure remained stable at rest and even during exercise in those taking sildenafil. These patients have had better heart index when doing or relying on exercises. Index of hemodynamic resistance in the system vessels was weaker in this group.

Such interference with the secondary endpoints calls for continuation of the investigation.

25% of patients have diastolic dysfunction with standard EF (LVEF) after the heart attack. This number was Andersen set out. Team also wants to learn more medicines, e.g. Aldosterone inhibitors. In addition, you will also learn information obtained during this investigation.

Experts have said that they are very interested in investigating mechanism of the recognized effect Viagra. It is very important to carry out complex examinations during which both causes and symptoms are examined. The thing is that occlusion pressure is not a cause of the problem but a symptom that needs to be removed. You have to find cause to solve this problem. Only then will it be solved. You have to eliminate the main disease.

In all cases, patients who had the heart attack with diastolic dysfunction should not give up on body burden, but they should be careful. We recommend doing exercises to stop Ohmings, discomfort, pain and breathing problems.